PATHOLOGY MCQ
GENETICS AND DISEASE
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Hemophilia (Xh) is a sex-linked trait in humans. If a son born to a couple has hemophilia but neither parent has hemophilia, what are the probable genotypes of the parents?
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XHXh and XHY
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XhXh and XHY
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XhXh and XhY
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XHXH and XhY
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Explanation:
Detailed explanation-1: -If a mother is heterozygous (a carrier) for hemophilia and the father does not have hemophilia, each son has a 1 in 2 (50%) chance of getting his mother’s hemophilia allele and having hemophilia.
Detailed explanation-2: -Hemophilia is & sex-linked recessive trait in humans If a father and & son are both hemophiliacs; but the mother Is normal; her genotype must be: 0 Xhy XhXh 0 XhXh XHXH.
Detailed explanation-3: -They may not have symptoms, but they can pass the condition on to their children. There’s a 50% chance that any children they have-boys or girls-will inherit hemophilia. Boys who do inherit hemophilia are more likely to have severe symptoms.
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