PATHOLOGY

Detailed explanation-1: -In males (who only have one X chromosome), a mutation in the copy of the gene on the single X chromosome causes the condition. Fathers cannot pass X-linked dominant conditions to their sons, but all daughters of affected fathers will be affected with the condition and can pass it on to their children.

Detailed explanation-2: -Males will always pass their X chromosome to their daughters and their Y chromosome to their sons. Because females have two X chromosomes, carriers have a second, normal (or ‘wild-type’) copy of the gene. This means that female carriers are usually not affected by X-linked recessive conditions, or affected only mildly.

Detailed explanation-3: -X linked Recessive Inheritance A male with an affected allele on his single X chromosome is hemizygous and can not transmit the disorder to their male offsprings, but all his daughters would be obligate carriers.

Detailed explanation-4: -Daughters have a 50% chance of inheriting the mutated X-linked gene from their mother and a 100% chance of inheriting the mutated X-linked gene from their father.