PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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In its heterozygous form this disease is less harmful. Although it protects individuals from malaria, a homozygous individual will die from the disease. The results of the disease are misshapen red blood cells. This disease shows a codominant inheritance pattern.
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Hemophilia
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Sickle Cell Anemia
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Huntington’s
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Cystic Fibrosis
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Explanation:
Detailed explanation-1: -One explanation for why heterozygous individuals might have less severe malaria infections is that some of their RBCs sickle when infected with the malaria parasite. The deformed cells are marked for destruction. When the RBCs are destroyed, so are the parasites.
Detailed explanation-2: -Cystic Fibrosis People with one normal copy of the CF allele are unaffected by CF, because they can produce enough CFTR to allow their cells to work properly. Two copies of the defective allele are needed to produce the disorder, which means the CF allele is recessive.
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