PATHOLOGY MCQ
GENETICS AND DISEASE
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Cystic fibrosis must be a dominant trait disorder hidden in both parents’ genotype, but not showing in the phenotype, that could be passed on to offspring.
|
|
|
Cystic fibrosis must be a recessive trait disorder hidden in both parents’ genotype, but not showing in the phenotype, that could be passed on to offspring.
|
|
|
Cystic fibrosis must be a dominant trait disorder hidden in one parents’ genotype, but not showing in the phenotype, that could be passed on to offspring.
|
|
|
Cystic fibrosis must be a recessive trait disorder hidden in one parents’ genotype, but not showing in the phenotype, that could be passed on to offspring
|
Detailed explanation-1: -Cystic fibrosis (CF) is a genetic disease. This means that CF is inherited. A child will be born with CF only if two CF genes are inherited-one from the mother and one from the father. A person who has only one CF gene is healthy and said to be a “carrier” of the disease.
Detailed explanation-2: -Cystic fibrosis is an example of a recessive disease. That means a person must have a mutation in both copies of the CFTR gene to have CF. If someone has a mutation in only one copy of the CFTR gene and the other copy is normal, he or she does not have CF and is a CF carrier.
Detailed explanation-3: -If you are both carriers, each pregnancy will have a 1 in 4, or 25 percent chance of being affected with cystic fibrosis.
Detailed explanation-4: -This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.