PATHOLOGY

PATHOLOGY MCQ

GENETICS AND DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Mendel’s law of independent assortment is least likely to be observed for ____ (3B3)
A
Genes on different chromosomes
B
Genes that are located close together on the same chromosome
C
Genes that are located far apart
D
Genes that are located on sex chromosomes
Explanation: 

Detailed explanation-1: -When genes are close together on a chromosome, the alleles on the same chromosome tend to be inherited as a unit more frequently than not. Such genes do not display independent assortment and are said to be linked.

Detailed explanation-2: -Recombination scrambles pieces of maternal and paternal genes, which ensures that genes assort independently from one another. It is important to note that there is an exception to the law of independent assortment for genes that are located very close to one another on the same chromosome because of genetic linkage.

Detailed explanation-3: -The allele received for one gene does not influence the allele received for another gene. Mendel’s experiment always portrayed that the combinations of traits of the progeny are always different from their parental traits. Based on this, he formulated the Law of Independent Assortment.

Detailed explanation-4: -Linked genes are exceptions to the law of independent assortment because two genes are located on the same chromosome, but this is generally mitigated when chromosomes cross over. One of the basic principles of inheritance or genetics is the law of independent assortment otherwise known as Mendel’s second law.

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