PATHOLOGY

Detailed explanation-1: -Most genetic disorders that result in sterility or childhood death are caused by recessive mutations, DNA sequence variants that are harmless when a person carries only one copy.

Detailed explanation-2: -Most genetic diseases are caused by recessive alleles because most genetic diseases are caused by a lack of a functional protein. Heterozygotes (two different alleles) for genetic disorders usually have sufficient dosage of the protein from the functional gene copy to have a normal life.

Detailed explanation-3: -Definition. Autosomal recessive is a pattern of inheritance characteristic of some genetic disorders. “Autosomal” means that the gene in question is located on one of the numbered, or non-sex, chromosomes. “Recessive” means that two copies of the mutated gene (one from each parent) are required to cause the disorder.