PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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slightly affected by the disease, showing some but not all of the symptoms
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not affected at all by the disease
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subjected to some environmental toxin that caused the disease in their children
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both affected by the disease
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Detailed explanation-1: -Most people who have recessive disorders are born to normal parents who are both heterozygotes–that is, those parents who are carriers of the recessive allele for the disorder but are phenotypically normal.
Detailed explanation-2: -The most common situation of an autosomal recessive disease occurs when the parents are each carrier or heterozygous (Dd). Children of carrier parents have a 25% chance of inheriting the disorder.
Detailed explanation-3: -The parents of a child with an autosomal recessive condition usually do not have the condition. Unaffected parents are called carriers because they each carry one copy of the mutated gene and can pass it to their children.
Detailed explanation-4: -Autosomal recessive disorders are typically not seen in every generation of an affected family. X-linked dominant disorders are caused by variants in genes on the X chromosome. In males (who have only one X chromosome), a variant in the only copy of the gene in each cell causes the disorder.