PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Silent mutations ____
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have no effect.
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change the amino acid.
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create a stop codon.
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are harmful.
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Explanation:
Detailed explanation-1: -Around 99.8% of genes that undergo mutations are deemed silent because the nucleotide change does not change the amino acid being translated. Although silent mutations are not supposed to have an effect on the phenotypic outcome, some mutations prove otherwise like the Multi-Drug Resistance Gene 1.
Detailed explanation-2: -Though recent studies suggest that silent mutations can affect the final protein structure, it is unknown if its position within the sequence is relevant.
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