PATHOLOGY

Detailed explanation-1: -Frameshift Mutation A frameshift mutation in a gene refers to the insertion or deletion of nucleotide bases in numbers that are not multiples of three.

Detailed explanation-2: -A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.

Detailed explanation-3: -Thus, if a mutation, for example, an insertion or a deletion of the nucleotide, occurs, this could result in the alteration of the reading frame. It completely changes the amino acid sequence. Such mutations are known as frameshift mutation (also called reading frame mutation, reading frame shift, or framing error).

Detailed explanation-4: -Deletion frameshift mutation: When in the nucleic acid, one or more nucleotides are deleted, resulting in reading frameshift. Insertion frameshift mutation: When in the nucleic acid, one or more nucleotides are added, resulting in reading frameshift.