PATHOLOGY

Detailed explanation-1: -The risk for two carrier parents to both pass the altered gene and have an affected child is 25% with each pregnancy.

Detailed explanation-2: -Tay–Sachs disease is an autosomal recessive genetic disorder, meaning that when both parents are carriers, there is a 25% risk of giving birth to an affected child with each pregnancy. The affected child would have received a mutated copy of the gene from each parent.

Detailed explanation-3: -1 in 2 (50%) chance the child inherits a faulty gene from one parent and becomes a carrier, but won’t have the condition themselves. 1 in 4 (25%) chance the child inherits a faulty gene from both parents and develops Tay-Sachs disease.

Detailed explanation-4: -50% (1 in 2) chance that the child gets a variant gene from one parent. When this happens, the child will be a carrier but won’t have Tay-Sachs. Since they’re a carrier, they may pass it to their children. 25% (1 in 4) chance that the child gets a variant gene from both parents.

Detailed explanation-5: -Tay-Sachs disease (TSD) is a fatal autosomal recessive genetic disorder, most commonly occurring in children. TSD is caused by mutations in the HEXA (hexosaminidase-A) gene localized on chromosome 15.