PATHOLOGY

Detailed explanation-1: -This disorder is caused by a defective allele for beta-globin, one of two polypeptides in hemoglobin, the oxygen-carrying protein in red blood cells. decreases. The molecules clump into long fibers, forcing cells into a distinctive sickle shape, which gives the disorder its name.

Detailed explanation-2: -Sickle cell disease is a genetic disorder caused by mutations in the beta globin genes that leads to faulty hemoglobin protein, called hemoglobin S. Hemoglobin S changes flexible red blood cells into rigid, sickle-shaped cells. These sickle cells can block blood flow, and result in pain and organ damage.

Detailed explanation-3: -Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disease have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

Detailed explanation-4: -Sickle Cell Anemia: occurs when an abnormal hemoglobin S gene is inherited from both parents. The red blood cells are normally shaped like a disc but the distorted red blood cells of sickle cell anemia are shaped like crescents.

Detailed explanation-5: -How Sickle Cell Trait is Inherited. If both parents have SCT, there is a 50% (or 1 in 2) chance that any child of theirs also will have SCT, if the child inherits the sickle cell gene from one of the parents. Such children will not have symptoms of SCD, but they can pass SCT on to their children.