PATHOLOGY

Detailed explanation-1: -The gene with the instructions for making factor is found only on the sex chromosome labeled X. If the gene is faulty, the result is hemophilia unless there is a dominant, normal gene on a matching X chromosome. Hemophilia is a sex-linked recessive disorder. These kinds of defects occur more often in men than in women.

Detailed explanation-2: -Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern . The genes associated with these conditions are located on the X chromosome, which is one of the two sex chromosomes . In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition.

Detailed explanation-3: -Diseases such as hemophilia and Duchenne muscular dystrophy occur from a recessive gene on the X chromosome.

Detailed explanation-4: -This means that males only have one allele for factor VIII and one allele for factor IX. Thus, if a male has a hemophilia allele on his only X chromosome, he will have the disorder. A female inherits two copies of the factor VIII or factor IX gene, one from her mother and one from her father.

Detailed explanation-5: -In an X-linked recessive inheritance pattern, the abnormal (mutated) gene is on the X chromosome. Duchenne muscular dystrophy, some types of colorblindness and hemophilia A are examples of X-linked recessive disorders.