PATHOLOGY

Detailed explanation-1: -Centimorgan (cM)/ Map unit is the unit used to express the physical distance between the genes. 1cM equals 1% Recombination frequency. Thus we can calculate the map distance of genes on a chromosome, if we know the percentage of recombinants in the offspring.

Detailed explanation-2: -A genetic map (also called a linkage map) shows the relative location of genetic markers (reflecting sites of genomic variants) on a chromosome.

Detailed explanation-3: -The genetic map distance is roughly proportional to the physical distance, i.e. the amount of DNA between two loci. For example, in Arabidopsis, 1.0 cM corresponds to approximately 150, 000bp and contains approximately 50 genes.

Detailed explanation-4: -Genetic maps are species-specific and comprised of genomic markers and/or genes and the genetic distance between each marker. These distances are calculated based on the frequency of chromosome crossovers occurring during meiosis, and not on their physical location on the chromosome.