PATHOLOGY

Detailed explanation-1: -CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. Repetitive DNA sequences, called CRISPR, were observed in bacteria with “spacer” DNA sequences in between the repeats that exactly match viral sequences.

Detailed explanation-2: -Clustered regularly interspaced short palindromic repeats (CRISPRs) are DNA sequences composed of a succession of repeats (23-to 47-bp long) separated by unique sequences called spacers. Polymorphism can be observed in different strains of a species and may be used for genotyping.

Detailed explanation-3: -Q: What is “CRISPR”? A: “CRISPR” (pronounced “crisper”) stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are the hallmark of a bacterial defense system that forms the basis for CRISPR-Cas9 genome editing technology.

Detailed explanation-4: -CRISPR sequences were found in nearly all archaeal genomes and in about half of bacterial genomes, rendering them the most widely distributed family of repeated sequences in prokaryotes. As of today, CRISPR sequences have not been found in any eukaryotic genome.

Detailed explanation-5: -One CRISPR definition is ‘A segment of DNA containing short repetitions of base sequences, involved in the defence mechanisms of prokaryotic organisms to viruses.