PATHOLOGY

PATHOLOGY MCQ

GENETICS AND DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the study of variations of responses to drugs related to variations in single genes?
A
Genotype
B
Phenotype
C
Pharmacogenetics
D
Pharmacogenomics
Explanation: 

Detailed explanation-1: -Pharmacogenetics research looks at variations in the human genome and ways in which genetic factors might influence how individuals respond to drugs.

Detailed explanation-2: -In pharmacogenomics, genomic information is used to study individual responses to drugs. When a gene variant is associated with a particular drug response in a patient, there is the potential for making clinical decisions based on genetics by adjusting the dosage or choosing a different drug, for example.

Detailed explanation-3: -What is pharmacogenomics? Pharmacogenomics (sometimes called pharmacogenetics) is a field of research that studies how a person’s genes affect how he or she responds to medications. Its long-term goal is to help doctors select the drugs and doses best suited for each person.

Detailed explanation-4: -Pharmacogenomics is the study of how genes affect a person’s response to drugs. This field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications that can be prescribed based on a person’s genetic makeup.

Detailed explanation-5: -Pharmacogenomics is also known as companion diagnostics, meaning tests being bundled with drugs. Examples include KRAS test with cetuximab and EGFR test with gefitinib.

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