PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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it is caused by an X-linked trait
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it is codominant with PKU
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it is caused by a dominant allele
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it becomes apparent when the child is about 2-3 years old
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Detailed explanation-1: -Huntington’s disease is an autosomal dominant disorder, which means that a person needs only one copy of the nontypical gene to develop the disorder. With the exception of genes on the sex chromosomes, a person inherits two copies of every gene-one copy from each parent.
Detailed explanation-2: -Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a mutation in the HD gene on chromosome 4. The causative mutation is an expansion of the CAG repeat at the 5′ end of the HD gene, resulting in abnormally expanded polyglutamine chain.
Detailed explanation-3: -Huntington’s disease is autosomal dominant, meaning inheritance of just a single copy of an abnormal chromosome from a biological parent is enough to cause it. If one parent carries the abnormal gene, each of their biological children has a 50 percent chance of Huntington’s disease inheritance.
Detailed explanation-4: -Huntington’s Disease (HD) is an inherited brain disorder. HD typically begins between the ages of 30-45, though onset may occur as early as the age of two or as late as the 70s. HD affects males and females equally and affects all ethnic and racial groups. More items