PATHOLOGY

Detailed explanation-1: -Definition. Sickle cell disease is a hereditary disease seen most often among people of African ancestry. Caused by mutations in one of the genes that encode the hemoglobin protein, the disease is inherited as an autosomal recessive trait.

Detailed explanation-2: -Autosomal recessive inheritance is a way a genetic trait or condition can be passed down from parent to child. A genetic condition can occur when the child inherits one copy of a mutated (changed) gene from each parent. The parents of a child with an autosomal recessive condition usually do not have the condition.

Detailed explanation-3: -Sickle cell disease (SCD) is a group of inherited red blood cell disorders.

Detailed explanation-4: -Autosomal genetic disorders refer to the disorders that cause due by mutations in autosomes. In the case of sickle cell anemia, a beta-hemoglobin gene is found on chromosome 11. It occurs when both parents carry the defective gene. Sickle cell anemia is an autosomal recessive genetic disorder.