PATHOLOGY

Detailed explanation-1: -Hemophilia is a sex-linked recessive disorder. The abnormal gene responsible for hemophilia is carried on the X chromosome. Males have one X chromosome and one Y chromosome.

Detailed explanation-2: -Diseases such as hemophilia and Duchenne muscular dystrophy occur from a recessive gene on the X chromosome.

Detailed explanation-3: -Hemophilia is an X-linked recessive hereditary disorder that classically affects males due to the presence of only one X chromosome in males. Females are usually carriers due to the presence of counterpart X chromosome, but many times manifestations of hemophilia are seen in heterozygous carrier females.

Detailed explanation-4: -X-linked disorders are caused by variants in genes on the X chromosome, one of the two sex chromosomes in each cell. In males (who have only one X chromosome), an alteration in the only copy of the gene in each cell is sufficient to cause the condition.

Detailed explanation-5: -Hemophilia is caused by a mutation or change, in one of the genes, that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or mutation can prevent the clotting protein from working properly or to be missing altogether. These genes are located on the X chromosome.