PATHOLOGY

Detailed explanation-1: -Mutation Generates New Alleles The whole human family is one species with the same genes. Mutation creates slightly different versions of the same genes, called alleles.

Detailed explanation-2: -New alleles can be formed as a result of mutation, this is the final source. Mutations are permanent changes in the sequences of DNA. It is the first step in creating a new DNA sequence for a specific gene that makes up a new allele.

Detailed explanation-3: -Autosomal dominant genetic disorders are caused by dominant alleles of a single gene on an autosome.

Detailed explanation-4: -The effects of the mutant version of the gene (allele) override the effects of the healthy version of the gene. So, the mutant allele causes disease symptoms even though a healthy allele is present.