PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following would result in a frameshift mutation?
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Insertions only
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Substitution only
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Deletion only
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Insertions and Deletions
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Explanation:
Detailed explanation-1: -Frameshift mutations arise when the normal sequence of codons is disrupted by the insertion or deletion of one or more nucleotides, provided that the number of nucleotides added or removed is not a multiple of three.
Detailed explanation-2: -An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.
Detailed explanation-3: -So the correct answer is ‘Either an insertion or a deletion of a base’.
There is 1 question to complete.