PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Engineering bacteria to produce insulin
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Crossing 2 varieties of apple
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Breeding a donkey and horse to make a mule
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Creating a polyploid banana tree
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Detailed explanation-1: -Recombinant DNA is a technology scientists developed that made it possible to insert a human gene into the genetic material of a common bacterium. This “recombinant” micro-organism could now produce the protein encoded by the human gene. Scientists build the human insulin gene in the laboratory.
Detailed explanation-2: -Recombinant human insulin is produced predominantly using E. coli and Saccharomyces cerevisiae for therapeutic use in human.
Detailed explanation-3: -’Recombinant human insulin’ became available in large amounts by recombinant DNA technology using fermentation in microorganisms (bacteria or yeast). Recombinant insulin has a superior level of purity and consistent quality compared with semisynthetic insulin.
Detailed explanation-4: -Bacteria can produce Human insulin in Recombinant DNA Technology because the genetic code for insulin is universal. Insulin is used to treat diabetes.
Detailed explanation-5: -Recombinant DNA technology requires both nucleases and ligases. II. Ligases produce nicks in the recombinant DNA molecule.