PATHOLOGY

Detailed explanation-1: -People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin “S.” Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped. This is commonly called sickle cell anemia and is usually the most severe form of the disease.

Detailed explanation-2: -The affected cells can clog up blood vessels preventing adequate blood flow. Sickled cells also have a shorter life span than their healthy counterparts. Fewer red blood cells means less oxygen is delivered to organs and tissues in the body.

Detailed explanation-3: -Sickle cell anemia is a genetic condition present from birth, with symptoms usually beginning to appear at about 4 months old. The main symptom of the condition is low red blood cell count, a form of anemia, which often causes pale skin and nails.

Detailed explanation-4: -It is marked by flawed hemoglobin. That’s the protein in red blood cells that carries oxygen to the tissues of the body. So, sickle cell disease interferes with the delivery of oxygen to the tissues.