PATHOLOGY MCQ
HAEMOPOIETIC SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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A 14-year-old boy presented to a hospital with enlarged submaxillary and cervical lymph nodes. A biopsy procedure was performed. Microscopical investigation revealed the disorder of a lymph node typical structure, a heterogeneous cellular population with a presence of giant multinuclear cells and plural one-nuclear big cells. There were also eosinocytes, neutrophils and lymphocytes in the cell infiltrate. In addition, sites of necrosis and sclerosis were found. What is the most likely diagnosis?
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Hyperplasia of lymphatic nodes
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Granulomatous lymphadenitis
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Purulent lymphadenitis
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Non-Hodgkin‘s lymphoma
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Lymphogranulomatosis
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Explanation:
Detailed explanation-1: -A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages that are transformed into epithelium like cells surrounded by a collar of mononuclear leukocytes, principally lymphocytes, and plasma cells.
Detailed explanation-2: -Giant cell tumors of soft tissue (GCT-STs) are rare neoplasms and are mainly seen in adults and in the elderly population, usually in the extremities. When evaluated along with clinical features, the cytological features are sufficient to distinguish GCT-STs from other more common tumors with giant cell morphology.
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