PATHOLOGY

Detailed explanation-1: -Reticulocytes in turn are generated in the bone marrow from mature erythroblasts by enucleation. After a brief period of time in the bone marrow, reticuloctyes are released into circulation, where they eliminate their residual RNA, and mature into erythrocytes.

Detailed explanation-2: -As reticulocytes mature, they lose the last residual RNA, and most are fully developed within one day of being released from the bone marrow into the blood. The reticulocyte count is a good indicator of the ability of your bone marrow to adequately produce RBCs (erythropoiesis).

Detailed explanation-3: -In the final stage of the maturation process, along with a dramatic reduction in cell size, basophilic pro-normoblasts lose their nuclei to become reticulocytes, which then enter the blood circulation as fully mature RBCs.