PATHOLOGY

Detailed explanation-1: -Where does hematopoiesis occur? The most common site of blood cell production is the spongy tissue inside of your bones called bone marrow. Hematopoiesis that occurs in your bone marrow is called medullary hematopoiesis. Blood cells get made in your bone marrow and released into your bloodstream.

Detailed explanation-2: -In humans, hematopoiesis begins in the yolk sac and transitions into the liver temporarily before finally establishing definitive hematopoiesis in the bone marrow and thymus. Experiments with human embryos confirm observations in the hemangioblast, a common precursor for endothelial and hematopoietic cells.

Detailed explanation-3: -Hematopoiesis in the bone marrow (BM) is the primary source of immune cells. Hematopoiesis is regulated by a diverse cellular microenvironment that supports stepwise differentiation of multipotent stem cells and progenitors into mature blood cells.