PATHOLOGY MCQ
HAEMOPOIETIC SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Spherocytic anemia is caused by ____
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mutation on gene that produce G6PD enzyme leave the membrane exposed to oxidation by free radicals
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mutation on gene lead to failure in ankyrin and spectrin production
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inherited defect on hemoglobin structure that caused crystallized hemoglobin and lead to change of RBC shape.
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None of the above
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Explanation:
Detailed explanation-1: -Mutations in ankyrin gene (ANK1) is the most common cause of HS in Northern European populations but is seen in only 5–10% of Japanese patients. The majority of them are familial mutations inherited in an autosomal dominant form.
Detailed explanation-2: -The primary defect in the hereditary spherocytosis (HS) syndromes is a qualitative or quantitative alteration in one or more erythrocyte membrane proteins. Mutation of the erythrocyte membrane protein ankyrin are the most common cause of typical, dominant HS.
There is 1 question to complete.