PATHOLOGY MCQ
HAEMOPOIETIC SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What does erythropoietin control?
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rate of erythrocyte production
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rate of leukocyte production
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rate of myloid production
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rate of stem cell production
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Explanation:
Detailed explanation-1: -The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival, proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly from fibroblasts in the renal cortex. Epo production is controlled at the transcriptional level.
Detailed explanation-2: -Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume.
Detailed explanation-3: -Human erythropoietin (EPO) is an N-linked glycoprotein consisting of 166 aa that is produced in the kidney during the adult life and acts both as a peptide hormone and hematopoietic growth factor (HGF), stimulating bone marrow erythropoiesis.
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