PATHOLOGY MCQ
HAEMOPOIETIC SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following do NOT stimulate erythropoietin production?
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Renal failure
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High altitude
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Hypoxia
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Pregnancy
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Explanation:
Detailed explanation-1: -The partial pressure of oxygen (pO2) directly regulates EPO production. The lower the pO2, the greater the production of EPO. Indirectly, low hemoglobin levels stimulate EPO production.
Detailed explanation-2: -The treatment of anemia in CKD patients usually involves the use of recombinant human erythropoietin (rHuEPO). The main cause of rHuEPO treatment failure is the loss or low iron availability.
Detailed explanation-3: -Epoetin is used to treat severe anemia in patients on kidney dialysis or for those not on dialysis. Epoetin may also be used to prevent or treat anemia that is caused by surgery or medicines (eg, zidovudine) that are used for other conditions, such as HIV or cancer.
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