PATHOLOGY

Detailed explanation-1: -[7] Myofibroblasts are present in both healthy and pathologic tissues and contain features of fibroblasts and smooth muscle cells. [3] These cells work in conjunction with vascular endothelial cells to form granulation tissue during times of wound healing.

Detailed explanation-2: -Studies now show that fibroblasts are involved in formation of the extracellular matrix and they control of the size of the extracellular matrix. Additionally they participate in the repair process by differentiating into myofibroblasts which are cells involved in the inflammatory response to injury.

Detailed explanation-3: -Myofibroblasts are the unique population of smooth muscle-like fibroblasts. These cells have a role in growth factors secretion, matrix deposition and degradation. Thereby, myofibroblast contributes in both human physiology and pathology.

Detailed explanation-4: -Myofibroblasts are contractile, -smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments.