PATHOLOGY

Detailed explanation-1: -A new network of blood vessels must be constructed so that the granulation tissue can be healthy and receive sufficient oxygen and nutrients. Myofibroblasts cause the wound to contract by gripping the wound edges and pulling them together using a mechanism similar to that of smooth muscle cells.

Detailed explanation-2: -In the proliferation phase, the provisional wound matrix formed during haemostasis is replaced by granulation tissue, consisting of a large amount of fibroblasts, granulocytes, macrophages, blood vessels, in complex with collagen bundles, which partially recovers the structure and function of the wounded skin [35].

Detailed explanation-3: -The proliferative phase of wound healing is when the wound is rebuilt with new tissue made up of collagen and extracellular matrix. In the proliferative phase, the wound contracts as new tissues are built.

Detailed explanation-4: -Proliferation – fibroblasts, supported by new capillaries, proliferate and synthesize disorganized ECM. Basal epithelial cells proliferate and migrate over the granulation tissue to close the wound surface.

Detailed explanation-5: -In the proliferation stage, your body creates scar tissue to repair your injury. This phase of healing starts within 24 – 48 hours, peaks at around 2 – 3 weeks after your injury and stops after around 4 – 6 months. This is the reason why you will still be experiencing symptoms a couple of weeks after your injury.