PATHOLOGY

Detailed explanation-1: -During the regeneration component, specialized tissue is replaced by the proliferation of surrounding undamaged specialized cells. In the repair component, lost tissue is replaced by granulation tissue which matures into scar tissue.

Detailed explanation-2: -Proliferative phase. The milestones during the proliferative phase include replacement of the provisional fibrin matrix with a new matrix of collagen fibers, proteoglycans, and fibronectin to restore the structure and function to the tissue.

Detailed explanation-3: -In the proliferation phase, the provisional wound matrix formed during haemostasis is replaced by granulation tissue, consisting of a large amount of fibroblasts, granulocytes, macrophages, blood vessels, in complex with collagen bundles, which partially recovers the structure and function of the wounded skin [35].

Detailed explanation-4: -Tissue repair is a simple linear process in which the growth factors cause cell proliferation, thus leading to an integration of dynamic changes that involve soluble mediators, blood cells, the production of the extracellular matrix, and the proliferation of parenchymal cells.

Detailed explanation-5: -Fibrosis is the replacement of normal tissue with scar tissue.