PATHOLOGY

Detailed explanation-1: -Loose connective tissue is composed of loosely woven collagen and elastic fibers. The fibers and other components of the connective tissue matrix are secreted by fibroblasts.

Detailed explanation-2: -Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans, glycosaminoglycans, and matricellular proteins, can be considered potent protagonists of fibroblast survival, migration, and metabolism.

Detailed explanation-3: -Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM) characteristic of these tissues.

Detailed explanation-4: -Dense connective tissues Dense regular connective tissue (Figure 4) has fibers arranged in neatly organized, parallel bundles. It has both collagen and elastic fibers, which provide great tensile strength and elasticity in one direction. This tissue has very few fibroblasts and almost no other cells.