PATHOLOGY

Detailed explanation-1: -Granulation tissue is considered a contractile organ, characterized histologically by the presence and proliferation of fibroblasts, keratinocytes, endothelial cells, new thin-walled capillaries, and inflammatory cell infiltration of the extracellular matrix.

Detailed explanation-2: -Cells and proliferating capillaries are the two major components of granulation tissue. The cells are chiefly fibroblasts and inflammatory cells-macrophages, lymphocytes, plasma cells, and neutrophils depending on the stage and development of the granula-tion tissue and the presence of infection.

Detailed explanation-3: -It can be explained by 5 P’s – Pink, Punctate haemorrhages, Pulseful, Painless, Pin head granulation.

Detailed explanation-4: -Granulation tissue is vascularized tissue that forms as chronic inflammation evolves. The new capillaries make the tissue appear pink and granular, thus the name. Histologically, one can observe macrophages and proliferating fibroblasts within granulation tissue.