PATHOLOGY

Detailed explanation-1: -The third phase of healing consists of remodeling, which begins two to three weeks after the onset of the lesion and can last for one year or more. The core aim of the remodeling stage is to achieve the maximum tensile strength through reorganization, degradation, and resynthesis of the extracellular matrix.

Detailed explanation-2: -Remodelling is the final phase of the healing process in which the granulation tissue matures into scar and tissue tensile strength is increased (Figure 23.5).

Detailed explanation-3: -The remodeling phase is also known as maturation. During remodeling, the water content of the wound reduces, and the collagen laid down during proliferation is gradually replaced by a more stable interwoven type III collagen.

Detailed explanation-4: -Epithelialization is the process by which cells from the epidermis at a wound’s edge proliferate and migrate to cover the surface of the cutaneous defect (Swaim et al. 2001). Wound contraction is a major component of second intention wound healing and the center for contraction is granulation tissue (Swaim et al.