PATHOLOGY

Detailed explanation-1: -Type III collagen fibrils are thinner than type I fibrils [19] and are present in high concentrations in skin, blood vessels and other tissues with large proportions of elastic fibers. During the healing process in tendon, a randomly-oriented initial network of mostly type III collagen is formed at the wound site [20].

Detailed explanation-2: -Type 1 and type III collagens are the most prevalent collagen fibers in skin tissue with type I being more predominant of the two. The proteins impart structural strength to human skin. Progressive collagen loss had been associated with aging resulting in the thinning and fragility of elderly skin.

Detailed explanation-3: -Nearly 28 types of collagen have been identified, but collagen type I is the most common in skin, bone, teeth, tendon, ligaments, vascular ligature, and organs. Collagen type II is present in the cartilages. For collagen type III, the skin, muscle, and blood vessels are the most common sources of this protein.

Detailed explanation-4: -The main difference between collagen 1 2 and 3 is that collagen 1 is most abundant in bones, tendons, ligaments, and in the skin while collagen 2 occurs in hyaline and articular cartilages and collagen 3 is the main component of reticular fibers which make a supporting mesh in soft tissues and organs.