PATHOLOGY

Detailed explanation-1: -Haemostasis Phase. At the time of injury, the fibrin clot forms the provisional wound matrix and platelets release multiple growth factors initiating the repair process.

Detailed explanation-2: -Fibrin Clot Formation. The final steps in the coagulation cascade involve the conversion of fibrinogen to fibrin monomers which polymerizes and forms fibrin polymer mesh and result in a cross-linked fibrin clot.

Detailed explanation-3: -Fibrinolytic System Fibrin clots build up as an immediate response to tissue injury, but need to be removed during the following tissue remodeling phase.

Detailed explanation-4: -Fibrin is essential for clot contraction because it propagates the platelet-generated contractile forces through the entire network that comprises a clot or thrombus. The structure and rheological properties of fibrin gels are important because they determine the degree of platelet-mediated contraction.

Detailed explanation-5: -Acute-swelling stage. Sub-acute – regenerative stage. Chronic – scar tissue maturation and remodelling stage.