PATHOLOGY

Detailed explanation-1: -The fibrotic scar is characterized by the deposition of extracellular matrix molecules that are otherwise scarcely expressed in the neural parenchyma such as collagens, laminins and fibronectin. These molecules are generated by stromal cells (myofibroblasts), which are normally absent from the CNS parenchyma.

Detailed explanation-2: -As part of the healing process, specialized cells called fibroblasts in adjacent areas of skin produce a fibrous connective tissue made up of collagen. The bundles formed by these whitish, rather inelastic fibres make up the bulk of the scar tissue.

Detailed explanation-3: -Scar tissue mechanics differ somewhat from normal connective tissue mechanics. Normal connective tissue is mature and stable, with limited pliability. Immature scar tissue is much more dynamic and pliable.