PATHOLOGY

Detailed explanation-1: -Proliferation phase As the inflammation subsides, proliferation becomes a major theme with the focus on covering the wound surface (i.e., re-epithelialization), restoring the vascular network and forming granulation tissue.

Detailed explanation-2: -Tissue repair is a natural process in which the primary goal is to restore the structure and function of the tissue following an injury.

Detailed explanation-3: -Proliferative phase. The milestones during the proliferative phase include replacement of the provisional fibrin matrix with a new matrix of collagen fibers, proteoglycans, and fibronectin to restore the structure and function to the tissue.

Detailed explanation-4: -The primary aim of the proliferation phase is to fill the wound defect. Fibroblasts migrate to the wound site and synthesize collagen and elastin fibers which form the extracellular matrix necessary for granulation tissue formation.