PATHOLOGY

Detailed explanation-1: -The ECM initially consists of type III collagen, which is a rapidly produced and a weaker form of collagen that is ultimately replaced by the stronger type I collagen at the end of wound healing and scar formation.

Detailed explanation-2: -Studies of the structure of alpha-chains revealed that type III collagen (embryonic collagen) is present in granulation tissues.

Detailed explanation-3: -In the early stages of granulation tissue production, proliferating fibroblasts produce primarily proteoglycans, while later they produce mostly type III collagen (Utsunomiya et al., 2005).

Detailed explanation-4: -Structure of Granulation Tissue The fibroblasts form type III collagen, a form of the protein collagen that is found in soft tissues in the body.

Detailed explanation-5: -Collagen III is the first to be synthesized in the early stages of wound healing and is replaced by collagen I, the dominant skin collagen. The initial random deposition of collagen during the granulation tissue formation is further enhanced by lysyl oxidase enzyme-induced covalent cross-linking.