PATHOLOGY

Detailed explanation-1: -Thrombin adheres with circulating Fib and convert into insoluble fibrin by forming a fibrin network. This fibrin network strengthens the initial platelet plug10.

Detailed explanation-2: -Platelets adhere to the damaged endothelium to form a platelet plug, temporarily sealing the break in the vessel wall.

Detailed explanation-3: -If one of your blood vessels gets damaged, it sends out signals to the platelets. The platelets then rush to the site of damage and form a plug (clot) to fix the damage. The process of spreading across the surface of a damaged blood vessel to stop bleeding is called adhesion.

Detailed explanation-4: -Fibrinogen from alpha granules acts as a link between GPIIb/IIIa receptors on different platelets. Once platelets have linked together, a temporary platelet plug has formed, which is later fortified by the coagulation cascade of secondary hemostasis.

Detailed explanation-5: -Blood clots are made up of tiny cells called platelets, bound into a meshwork of proteins such as fibrin and collagen. For platelets to stick together, proteins called integrins are needed, which in turn are activated by another protein called kindlin-3.