PATHOLOGY

Detailed explanation-1: -Neutrophils are the dominant immune cells for the first 4 to 24 hours postinjury, after which macrophages predominate.

Detailed explanation-2: -Neutrophils are the initial cells and most predominant in the acute phase of inflammation. Neutrophils contain granules rich with lysozyme, matrix metalloproteinases, myeloperoxidase which are released on the foreign or self-antigen leading to its destruction.

Detailed explanation-3: -Cellular Phase. The predominant cell of acute inflammation is the neutrophil. They are attracted to the site of injury by the presence of chemotaxins, the mediators released into the blood immediately after the insult.

Detailed explanation-4: -Macrophages and dendritic cells process and present the antigen to immunocompetent cells and thus are critical mediators in the development of immune reactions. The macrophage is probably the most important cell in chronic inflammation because of the great number of biologically active products it produces [44].

Detailed explanation-5: -M1 macrophages are proinflammatory, while M2 macrophages are mostly anti-inflammatory.