PATHOLOGY

Detailed explanation-1: -Wound healing is classically divided into 4 stages: (A) hemostasis, (B) inflammation, (C) proliferation, and (D) remodeling. Each stage is characterized by key molecular and cellular events and is coordinated by a host of secreted factors that are recognized and released by the cells of the wounding response.

Detailed explanation-2: -The wound healing process is usually characterized as four sequential but overlapping phases: haemostasis (0–several hours after injury), inflammation (1–3 days), proliferation (4–21 days) and remodelling (21 days–1 year) [1].

Detailed explanation-3: -Inflammation, the next stage of wound healing occurs within the first 24 hours after injury and can last for up to 2 weeks in normal wounds and significantly longer in chronic non-healing wounds (Figure 23.3).

Detailed explanation-4: -Inflammatory phase – This phase begins at the time of injury and lasts up to four days. Proliferative phase – This phase begins about three days after injury and overlaps with the inflammatory phase. Remodeling phase – This phase can continue for six months to one year after injury.