PATHOLOGY

Detailed explanation-1: -Factors that can slow the wound healing process include: Dead skin (necrosis) – dead skin and foreign materials interfere with the healing process. Infection – an open wound may develop a bacterial infection. The body fights the infection rather than healing the wound.

Detailed explanation-2: -Cardiovascular conditions are among the most detrimental, but diabetes and immunodeficiency conditions can also slow wound repair. Prescription medications can have a negative effect on healing.

Detailed explanation-3: -Although the elderly can heal most wounds, they have a slower healing process, and all phases of wound healing are affected. The inflammatory response is decreased or delayed, as is the proliferative response. Remodeling occurs, but to a lesser degree, and the collagen formed is qualitatively different.

Detailed explanation-4: -Stress has been shown to have a negative impact on wound healing. Although both the direct and indirect mechanisms of stress may be responsible for slowed healing, the most prominent impact is through the effects of stress on cellular immunity.