PATHOLOGY

Detailed explanation-1: -Type II epithelial-mesenchymal transition is associated with tissue healing, regeneration, and fibrosis. Such an event, linked to tissue repair, creates fibroblasts and other cells related to the objective of reconstructing tissues resulting from traumas and inflammation.

Detailed explanation-2: -The proliferative or granulation phase does not occur at a discrete time, but is ongoing all the time in the background. By days 5 through 7, the fibroblasts have started to lay down new collagen and glycosaminoglycans. These proteoglycans form the core of the wound and help stabilize the wound.

Detailed explanation-3: -The second phase of wound healing is called the Inflammatory Phase. It involves phagocytic cells that release reactive oxygen species, lasting for up to seven days in acute wounds and longer in chronic wounds.

Detailed explanation-4: -Abstract. Fibroblasts are critical in supporting normal wound healing, involved in key processes such as breaking down the fibrin clot, creating new extra cellular matrix (ECM) and collagen structures to support the other cells associated with effective wound healing, as well as contracting the wound.

Detailed explanation-5: -Acute Inflammatory Phase: Day 1-7. Inflammation has a bad reputation, but acute (fresh) inflammation is actually essential for tissue repair. Fibroblastic Repair/Subacute Phase: Can begin at Day 4, up to 6 weeks. Remodelling Phase: As early as 2-3 weeks, up to months or years.