PATHOLOGY

Detailed explanation-1: -The third phase of healing consists of remodeling, which begins two to three weeks after the onset of the lesion and can last for one year or more. The core aim of the remodeling stage is to achieve the maximum tensile strength through reorganization, degradation, and resynthesis of the extracellular matrix.

Detailed explanation-2: -Remodeling or also known as maturation phase is the fourth and final phase in wound healing and lasts from 21 days up to 2 years. In this final and longest phase, collagen synthesis is ongoing in order to strengthen the tissue.

Detailed explanation-3: -Remodelling is the final phase of the healing process in which the granulation tissue matures into scar and tissue tensile strength is increased (Figure 23.5).

Detailed explanation-4: -The remodeling phase is also known as maturation. During remodeling, the water content of the wound reduces, and the collagen laid down during proliferation is gradually replaced by a more stable interwoven type III collagen.

Detailed explanation-5: -Finally, the body will convert this granulation tissue into a scar; this is known as the remodelling phase. The remodelling phase is a lengthy process that can take up to 1 year to complete; during this time the scar often becomes smaller and more pale in colour.