PATHOLOGY

Detailed explanation-1: -The epicardium, or the innermost layer of the pericardium, is the outermost layer of the heart itself. It is composed of mesothelial cells, fat, and connective tissue. It is adjacent to the myocardium, the middle muscular layer. The innermost layer is referred to as the endocardium.

Detailed explanation-2: -The epicardium is the outermost layer of the heart. It is actually the visceral layer of the serous pericardium, which adheres to the myocardium of the heart. Histologically, it is made of mesothelial cells, the same as the parietal pericardium.

Detailed explanation-3: -Epicardium: Outermost Layer of the Heart Wall The epicardium is sometimes referred to as the visceral pericardium. This is because it is composed of connective tissue that, in part, connects to the pericardium and forms its second layer. The epicardium has an important function within the cardiovascular system.