PATHOLOGY

Detailed explanation-1: -The fusion of the phagosome with lysosomes forms the mature phagolysosome (PL) which has full degradative and microbicidal capacity. Heterotypic fusion between the phagosome and lysosome is imperative for phagocytes to carry out their functions in immunity and homeostasis and is a tightly regulated process.

Detailed explanation-2: -Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP.

Detailed explanation-3: -A phagosome is a vesicle that forms by invagination of the plasma membrane with its associated lipids and proteins during phagocytosis of microbes or microbial proteins.

Detailed explanation-4: -In biology, a phagolysosome, or endolysosome, is a cytoplasmic body formed by the fusion of a phagosome with a lysosome in a process that occurs during phagocytosis.

Detailed explanation-5: -Lysosomes are polymorphic organelles because of its different shape and functions. Heterolysosomes are formed by the fusion of primary lysosome and phagosome. It is also known as digestive vacuoles or heterophagosomes.