PATHOLOGY

Detailed explanation-1: -For cases of allergic and idiopathic angioedema, antihistamines and oral steroids (steroid tablets) can be used to relieve the swelling. Drug-induced angioedema can usually be treated by using an alternative medication to treat whatever underlying condition you have.

Detailed explanation-2: -Antihistamines don’t actually reduce histamine release. They only block histamine receptors, preventing you from feeling the symptoms. You may need a round-the-clock blockade of the H1 and H2 receptors, every 12 hours.

Detailed explanation-3: -In more severe cases of histamine intolerance, you may experience: abdominal cramping. tissue swelling. high blood pressure.

Detailed explanation-4: -In the human body, histamine is metabolized in two ways: (1) extracellular oxidative deamination of the primary amino group by the enzyme diamine oxidase (DAO) and (2) intracellular methylation of the imidazole ring by the enzyme histamine N-methyltransferase.