PATHOLOGY

Detailed explanation-1: -Recipients with blood type B… can receive a kidney from blood types B and O. Recipients with blood type AB… can receive a kidney from blood types A, B, AB and O (AB is the universal recipient: recipients with AB blood are compatible with any other blood type)

Detailed explanation-2: -The immune response to a transplanted organ consists of both cellular (lymphocyte mediated) and humoral (antibody mediated) mechanisms. Although other cell types are also involved, the T cells are central in the rejection of grafts. The rejection reaction consists of the sensitization stage and the effector stage.

Detailed explanation-3: -This is because the person’s immune system detects that the antigens on the cells of the organ are different or not “matched.” Mismatched organs, or organs that are not matched closely enough, can trigger a blood transfusion reaction or transplant rejection.

Detailed explanation-4: -The immune system’s white blood cells make specific proteins called antibodies and special cells called T cells that destroy the foreign cells. A transplanted organ is made entirely of cells with foreign (“nonself”) antigens which means the body will attack the transplanted organ.