PATHOLOGY

Detailed explanation-1: -The first stages of B Cell development take place in complex microenvironments created by the stromal cells of the bone marrow known as “niches” from which come the stimuli and factors required to initiate a series of cell signals.

Detailed explanation-2: -In addition to this immune function, B cells have a close and multifaceted relationship with bone cells. B cells differentiate from hematopoietic stem cells (HSCs) in supportive niches found on endosteal bone surfaces.

Detailed explanation-3: -Bone marrow is major organ for the development and maturation of B cells. B cells are generated from HSCs and developed in bone marrow before they egress into peripheral blood to reach peripheral lymphoid organs. Specific cellular niches for B-cell development include CXCL12-expressing cells and IL-7-expressing cells.